Onychomycosis affects about 15% of the population. This disease causes physical\nand psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels,\ncolloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity\nof oral drugs. Currently, the most common topical formulations (creams and lotions) present a low\ndrug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously\nimprove the effectiveness of treatment with increased patient compliance. These formulations leave a\npolymer film on the nail plate after solvent evaporation. The duration of the film residence in the nail\nconstitutes an important property of nail lacquer formulation. In this study, a polyurethane polymer\nwas used to delivery antifungals drugs, such as terbinafine hydrochloride (TH) and ciclopirox olamine\n(CPX) and the influence of its concentration on the properties of nail lacquer formulations was\nassessed. The nail lacquer containing the lowest polymer concentration (10%) was the most effective\nregarding the in vitro release, permeation, and antifungal activity. It has also been demonstrated that\nthe application of PU-based nail lacquer improves the nail plate, making it smooth and uniform and\nreduces the porosity contributing to the greater effectiveness of these vehicles. To conclude, the use\nof polyurethane in nail formulations is promising for nail therapeutics.
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